Question 5 (interventional)
In patients with critical bleeding requiring massive transfusion, what is the effect of non-transfusion interventions to increase haemoglobin concentration on morbidity, mortality and need for RBC transfusion?
RBC, red blood cell
Non-transfusion interventions to increase haemoglobin concentration (e.g. iron and erythropoiesis-stimulating agents, ESAs) are not applicable in the setting of critical bleeding requiring massive transfusion. The review did not include a search for synthetic oxygen-carrying solutions or cell salvage techniques.
A systematic review of cell salvage techniques is included in other modules of these guidelines.
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