Patient Blood Management Guideline: Module 1 HOME

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Future directions

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Evidence gaps and areas of future research

Patient Blood Management Guidelines: Module 1

Critical Bleeding Massive Transfusion

| Future directions |

5.1 Evidence gaps and areas of future research

5.1.1 Effect of physiological parameters on outcomes

Question 1 (prognostic)

In patients with critical bleeding requiring massive transfusion, what is the effect of variation of physiologic, biochemical and metabolic (including temperature) parameters on morbidity, mortality and transfusion rate?

In patients with critical bleeding requiring massive transfusion, accepted clinical practice is to strive to maintain normal physiologic, biochemical and metabolic parameters. It is therefore not practical to undertake RCTs in this area. Nevertheless, the review identified sufficient evidence to support the currently accepted clinical practice, and this is addressed in practice points 1 and 2. It is debatable whether or not this is an evidence gap, but further research is recommended.