The development of evidence-based clinical practice guidelines that meet NHMRC standards involves developing a set of clinical research questions, systematically reviewing the scientific literature for evidence related to those questions, and then developing and grading recommendations based on a structured assessment of the evidence.⁸ The methods used in applying this process to the development of this module are outlined below, and are given in full in the accompanying two-volume technical report.^2,3 A summary of the overall process for development of this module is given in Appendix D.