Between July and November 2008, the relevant clinical research questions for this module were developed, prioritised, combined and refined by the EWG, the NHMRC GAR consultants and the CRG (Appendix A). The process resulted in different types of questions, as shown in Table 2.1.

Question type	Answered based on	Uses	Location in document
Specific to this module	Systematic review	Used to develop: recommendations practice points	Questions listed in Box 2.1 and discussed in Chapter 4
Generic (i.e. relevant to all six modules in the series)	Systematic review	Used to develop: recommendations practice points	Questions listed in Box 2.1 and discussed in Chapter 4
Background specific to this module	Background material	Used to: capture information considered as being outside the scope of the systematic review questions provide general information for the guidelines.	Questions listed in Box 2.2 and discussed in Chapter 3

The specific, generic and background questions were crafted in such a way that they attempted to provide answers in clinically relevant areas of uncertainty; however, it was recognised that in some areas there would be little or no high-quality published evidence. The questions were further refined through consultation among the systematic reviewer, CRG, NBA and NHMRC GAR consultants. Details of research question criteria are presented in Volume 1 of the technical report.²