Patient Blood Management Guideline: Module 1 HOME

l

Future directions

l

Triggers for blood component transfusion

Patient Blood Management Guidelines: Module 1

Critical Bleeding Massive Transfusion

| Future directions |

5.1 Evidence gaps and areas of future research

5.1.8 Triggers for blood component transfusion

Question 8 (prognostic)

In patients with critical bleeding requiring massive transfusion, at what INR (or PT/APTT) for FFP, fibrinogen level for cryoprecipitate and platelet count for platelets concentrates should patients be transfused to avoid risks of significant adverse events?

APTT, activated partial thromboplastin time; FFP, fresh frozen plasma; INR, international normalised ratio; MTP, massive transfusion protocol; PT, prothrombin time

This question overlaps with questions 2 and 7. In the setting of critically bleeding patients requiring massive transfusion, the systematic review found no studies of transfusion triggers for FFP, platelets, cryoprecipitate or fibrinogen concentrate.

Further research is needed into transfusion triggers for FFP, platelets, cryoprecipitate or fibrinogen concentrate.